Version 2.1
Last update: Mon, 24 Aug 2009

Homophila utilizes the sequence information of human disease genes from the NCBI OMIM (Online Mendelian Inheritance in Man) database in order to determine if sequence homologs of these genes exist in the current Drosophila sequence database (FlyBase). Sequences are compared using NCBI's BLAST program. The database is updated weekly and can be searched by human disease, gene name, OMIM number, title, subtitle and/or allelic variant descriptions.

This analysis is discussed in detail in the following publications:

Reiter LT, Potocki L, Chien S, Gribskov M, Bier E., "A Systematic Analysis of Human Disease-Associated Gene Sequences In Drosophila melanogaster," Genome Research 11:1114–1125, Cold Spring Harbor Labratory Press.

Chien S, Reiter LT, Bier E, Gribskov M., "Homophila: human disease gene cognates in Drosophila", Nucleic Acids Research, 2002, Vol. 30, No. 1 149-151

Tab delimited flatfiles are now available for download. See table below for links.

Current statistics
OMIM entries having allellic variants 2325
OMIM entries having protein reference sequences 2287
H. sapiens reference sequences 3975
Protein sequences matched against D. melanogaster Entire BLAST dataset
E-value < 10-10
E-value < 10-50
E-value < 10-100
E-value < 10-200
Search for:
Diseases Titles Subtitles Allelic variants
E-value cutoff: